Doctors Diagnose Rare Syphilis in Elderly Man After Complex Symptoms

Extended summary

Published: 07.11.2025

In a perplexing case, medical professionals faced challenges diagnosing a rare presentation of syphilis in an elderly man who had been married for several years. The patient exhibited a combination of symptoms, including a rash, malaise, and issues with his liver and kidneys, alongside facial paralysis and swelling. These symptoms ultimately led to the identification of syphilis, although the specific manifestation affecting his liver is uncommon, complicating the diagnosis.

Understanding Syphilis Stages

Syphilis is a sexually transmitted infection that progresses through distinct stages. The initial phase, known as primary syphilis, is characterized by the appearance of a painless sore, or chancre, at the site of infection approximately one month after exposure. This sore typically heals on its own. Following this, secondary syphilis can occur, which is systemic and presents with symptoms such as rash, malaise, joint pain, fever, and sore throat, similar to those experienced by the patient. This stage typically arises within the first year following an untreated primary infection. If left untreated, the disease can enter a latent phase before potentially advancing to tertiary syphilis, which can severely affect the heart, central nervous system, and other vital organs.

Challenges in Diagnosis

The rarity of liver involvement in syphilis—occurring in less than 10% of cases—posed a significant diagnostic challenge for the medical team. The doctors concluded that the patient was likely in the secondary stage of syphilis, as his symptoms aligned with this phase. However, the timeline of his infection raised questions. The medical professionals noted that secondary syphilis usually manifests within four years of the primary infection, which suggests that the man could have had a more recent exposure that had not been reported. It was also considered that the patient’s use of an immunosuppressive drug for his facial paralysis might have reactivated a latent infection, although this would typically present as a late-stage infection rather than secondary syphilis.

Implications for Public Health

Upon successfully diagnosing and treating the man with antibiotics, he made a full recovery. The case has prompted local health authorities to investigate further, aiming to identify and inform the man’s sexual partners about the potential risk of syphilis transmission. The situation underscores the importance of public health initiatives in tracking sexually transmitted infections and ensuring that individuals receive appropriate care and treatment.

Conclusion

This case highlights the complexities involved in diagnosing syphilis, particularly when it presents with atypical symptoms. The challenges faced by the medical team reflect broader issues in the detection and management of sexually transmitted infections, emphasizing the need for ongoing awareness and education surrounding these diseases. While the patient’s recovery is a positive outcome, the lingering questions about the source and timing of his infection serve as a reminder of the importance of thorough sexual health histories in clinical practice.

Source: Ars Technica

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